Patent assignee · US · COMPANY

Signal Pharmaceuticals, LLC

161Patents
101Active
161Granted
52Portfolio score

Filing activity: Apr 14, 1992 → Mar 29, 2022 · 17 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US7981893B2 Heteroaryl compounds, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 73 Active
US5830651A Human oligodendroglial progenitor cell line Chemistry; Metallurgy 47 Expired
US8383634B2 Methods of treatment using heteroaryl compounds and compositions thereof Chemistry; Metallurgy 45 Active
US8492381B2 Pyrazino[2,3-b]pyrazine mTOR kinase inhibitor for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway Chemistry; Metallurgy 41 Active
US8110578B2 Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway Chemistry; Metallurgy 39 Active
US7129242B2 Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto Emerging Cross-Sectional Technologies 39 Expired
US8372976B2 Methods of treatment comprising the administration of heteroaryl compounds Chemistry; Metallurgy 38 Active
US6291456A Compounds and methods for modulation of estrogen receptors Chemistry; Metallurgy 36 Expired
US7723340B2 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 34 Active
US5811428A Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions Chemistry; Metallurgy 33 Expired
US6331562A Compounds and methods for modulation of estrogen receptors Chemistry; Metallurgy 33 Expired
US7521446B2 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 32 Active
US7968556B2 Heteroaryl compounds, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 30 Active
US7759342B2 Methods of treatment and prevention using haloaryl substituted aminopurines Human Necessities 29 Active
US6897231B2 Indazole derivatives as JNK inhibitors and compositions and methods related thereto Chemistry; Metallurgy 27 Expired
US9139534B2 Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 25 Active
US9512124B2 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 24 Active
US8158635B2 Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9H-purin-2-ylamino]-cyclohexan-1-ol, compositions thereof, and uses therewith Human Necessities 23 Active
US5939421A Quinazoline analogs and related compounds and methods for treating inflammatory conditions Chemistry; Metallurgy 23 Expired
US5948885A Mitogen-activated protein kinase p38-2 and methods of use therefor Human Necessities 22 Expired
US8101588B2 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith Chemistry; Metallurgy 21 Active
US6593322B1 Compounds and methods for modulation of estrogen receptors Chemistry; Metallurgy 20 Expired
US9365524B2 Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use Chemistry; Metallurgy 20 Active
US5935966A Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions Chemistry; Metallurgy 19 Expired
US8440661B2 Methods of modulating inflammatory cell recruitment and gene expression using haloaryl substituted aminopurines Human Necessities 19 Active

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.