Method for preparing nilotinib
US10000470B1 · kind B1 · utility
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20Claims
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Key dates
| Filing date | May 26, 2015 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | May 26, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing nilotinib includes the following steps: performing an aminocarbonylation reaction on a compound A and 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline to obtain an amination product; and performing deprotection treatment of an R group on the amination product to obtain the nilotinib, wherein the compound A has a structure shown in formula I, and in formula I, an R group is selected from benzyl, —COCF3, —CHO or —CO2R′, where an R′ group is C1˜C10 alkyl, C1˜C3 alkoxy ethyl or C7˜C19 aralkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.