Substituted thiohydantoin derivatives as androgen receptor antagonists

US10000502B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Gilles Bignan · Bound Brook, US
• Peter J. Connolly · New Providence, US
• Ian Hickson · Birtley, GB
• Lieven Meerpoel · Beerse, BE
• Vineet Pande · Vosselaar, BE
• Zhuming Zhang · Fryeburg, US
• Jonathan Branch · Hatfield, US
• Christian Rocaboy · Murcia, ES
• Luis B. Trabalón Escolar · Murcia, ES

Key dates

• Filing date: Jan 11, 2017
• Grant date: Jun 19, 2018
• Expiry date: Jan 11, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.