Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus
US10000555B2 · kind B2 · utility
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Key dates
| Filing date | Nov 1, 2012 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | Mar 9, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.