Antibody variants having modifications in the constant region
US10000570B2 · kind B2 · utility
1Cited by
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17Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 15, 2015 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | Jun 15, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.