LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
US10000746B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | May 28, 2014 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | May 28, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided.
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