Biochemical markers for pulmonary and other diseases
US10001490B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jan 8, 2015 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | Jan 8, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7052
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided is a method of bioassay for the quantification of peptide fragments elevated in lung diseases such as COPD, SCC, or IPF. The peptide fragments comprise a neo-epitope formed at a cleavage site by cleavage in vivo of elastin by a proteinase. In the method a sample is contacted with an antibody having specific binding affinity for the neo-epitope amino acid sequence and determining the level of binding is determined where the antibody binds one of the following terminal sequences: . . . FGPGVV, . . . VPGLGV or IKAPKL . . . . Also provided are antibodies and immunoassay kits for use in such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.