Production and use of bacterial histamine
US10004770B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 10, 2016 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Oct 10, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/335
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.