Compositions and methods of enhancing immune responses

US10004798B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Walter Bottje · Fayetteville, US
• Billy Hargis · Fayetteville, US
• Luc Berghman · College Station, US
• Young Min Kwon · West Fork, US
• Kimberly Cole · Raymond, US
• Mandy Cox · Fayetteville, US
• Sherryll Layton · Fayetteville, US

Key dates

• Filing date: Dec 16, 2015
• Grant date: Jun 26, 2018
• Expiry date: Dec 16, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.