Antibody evolution immunogens

US10004800B2 · kind B2 · utility

Assignees

• Duke University · US
• LOS ALAMOS NATIONAL SECURITY, LLC · US
• The Trustees of the University of Pennsylvania · US
• TRUSTEES OF BOSTON UNIVERSITY · US
• The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Barton F. Haynes · Durham, US
• Hua-Xin Liao · Durham, US
• Rebecca M. Lynch · Rockville, US
• Tongqing Zhou · Boyds, US
• Feng Gao · Hoover, US
• Scott Boyd · Palo Alto, US
• George M. Shaw · Birmingham, US
• Beatrice H. Hahn · Birmingham, US
• Thomas B. Kepler · Boston, US
• Bette T. Korber · Los Alamos, US
• Peter Kwong · Washington, US
• John Mascola · Rockville, US

Key dates

• Filing date: Sep 12, 2013
• Grant date: Jun 26, 2018
• Expiry date: Sep 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).