Compound and analogues for tracing histone acetylation inhibitors PET imaging for diagnosis and treatment of tumors
US10005727B2 · kind B2 · utility
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Key dates
| Filing date | Oct 6, 2016 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Oct 6, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with HDAC overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.