Methods for producing viloxazine salts and novel polymorphs thereof
US10005743B2 · kind B2 · utility
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6References
12Claims
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Key dates
| Filing date | Jun 24, 2016 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Jun 24, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D265/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
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