Patent · US Active

O-demethylating process of methoxy substituted morphinan-6-one derivatives

US10005791B2 · kind B2 · utility

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13Claims

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Assignee

NORAMCO, LLC · US

Inventors

Georg Weigl · Regensburg, DE
Dominik Stefan Stämpfli · Schaffhausen, CH
Nelli Maurer · Schaffhausen, CH

Key dates

Filing date	Apr 7, 2015
Grant date	Jun 26, 2018
Priority date	—
Expiry date	Apr 7, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D489/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to an improved process for O-demethylating methoxy substituted morphinan-6-one derivatives using AlCl3 as a demethylating agent in a reaction-inert solvent having a water content ranging from 0.1% wt to 0.8% wt. 10.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.