Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors

US10005792B2 · kind B2 · utility

Assignee

• CTXT PTY LTD · AU

Inventors

• Ylva Elisabet Bergman · Elmore, AU
• Romina Lessene · Melbourne, AU
• Danny Ganame · Melbourne, AU
• Richard Charles Foitzik · Elmore, AU
• Benjamin Joseph Morrow · Melbourne, AU
• Michelle Ang Camerino · Melbourne, AU
• Scott Raymond Walker · Melbourne, AU
• H. Rachel Lagiakos · Elmore, AU
• John Feutrill · Elmore, AU
• Paul Anthony Stupple · Elmore, AU

Key dates

• Filing date: Sep 3, 2015
• Grant date: Jun 26, 2018
• Expiry date: Sep 3, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.