Amide compounds for treatment of complement mediated disorders

US10005802B2 · kind B2 · utility

Assignee

• Achillion Pharmaceuticals, Inc. · US

Inventors

• Jason Allan Wiles · Madison, US
• Avinash Phadke · Branford, US
• Milind Deshpande · Madison, US
• Atul Agarwal · Hamden, US
• Dawei Chen · Middletown, US
• Venkat Rao Gadhachanda · Hamden, US
• Akihiro Hashimoto · Branford, US
• Godwin Pais · Hamden, US
• Qiuping Wang · Bethany, US
• Xiangzhu Wang · Madison, US

Key dates

• Filing date: Aug 24, 2016
• Grant date: Jun 26, 2018
• Expiry date: Aug 24, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade in the alternative complement pathway. The inhibitors of factor D described herein reduce the excessive activation of complement.