Anti-transglutaminase 2 antibodies
US10005846B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | May 24, 2013 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Dec 15, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.