Recombinant polypeptide production
US10006026B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Mar 12, 2014 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Mar 12, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/178
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microRNA activity level. In one embodiment, a microRNA activity level is increased. In another embodiment, a microRNA activity level is decreased. In a more particular embodiment, the mammalian cells have a reduced miRNA-let-7a activity level.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.