Hairpin mRNA elements and methods for the regulation of protein translation
US10006049B2 · kind B2 · utility
7Cited by
2References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 16, 2014 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | May 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/105
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel mRNA elements capable of forming hairpin, double-stranded RNA structures independent of other non-coding RNAs. These mRNAs are stably expressed, lack polyadenylation tails, and allow minimal protein translation except when in the presence of specific proteins. Also provided, are compositions and kits comprising the mRNA element, as well as methods for its use in the regulation of protein translation. Advantageously, the disclosed elements represent a novel tool useful in regulating the expression of a wide variety of proteins of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.