Laglidadg homing endonuclease cleaving the C-C chemokine receptor type-5 (CCR5) gene and uses thereof
US10006052B2 · kind B2 · utility
13Cited by
0References
14Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | May 28, 2014 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | May 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.