Process line for the production of freeze-dried particles

US10006706B2 · kind B2 · utility

Assignee

• Sanofi Pasteur SA · FR

Inventors

• Bernhard Luy · Glückstadt, DE
• Matthias Plitzko · Neuenbürg, DE
• Manfred Struschka · Auggen, DE

Key dates

• Filing date: Oct 4, 2012
• Grant date: Jun 26, 2018
• Expiry date: Oct 4, 2032

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F26B5/065
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.