Thermally modulated variable restrictor for normalization of dynamic split ratios
US10006890B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 2014 |
| Grant date | Jun 26, 2018 |
| Priority date | — |
| Expiry date | Feb 12, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/3038
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.