Substituted spirocyclic inhibitors of autotaxin

US10011601B2 · kind B2 · utility

Assignee

• X-Rx, Inc. · US

Inventors

• Lee Babiss · Waltham, US
• Matthew Clark · Waltham, US
• Anthony D. Keefe · Cambridge, US
• Mark J. Mulvihill · Melville, US
• Haihong Ni · Shanghai, CN
• Louis Renzetti · Waltham, US
• Frank Ruebsam · Beijing, CN
• Ce Wang · Beijing, CN
• Zhifeng Xie · Beijing, CN
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Apr 3, 2015
• Grant date: Jul 3, 2018
• Expiry date: Apr 3, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.