Method for the purification of decitabine
US10011626B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 25, 2016 |
| Grant date | Jul 3, 2018 |
| Priority date | — |
| Expiry date | Jul 23, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step comprises adding an anti-solvent, such as ethanol, to the solution or suspension. The forming step may further comprise after adding ethanol to provide a mixture of dimethylacetamide and ethanol: cooling the mixture; isolating the solid decitabine present in the cooled mixture; and evaporating residual dimethylacetamide and ethanol from the solid decitabine to provide the purified decitabine. The mixture of dimethylacetamide and ethanol may be heated. The purification method preferably results in decitabine having a ratio of the β-anomer of decitabine to the α-anomer of decitabine of at least about 99.9:0.1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.