Ultra-pure agonists of guanylate cyclase C, method of making and using same

US10011637B2 · kind B2 · utility

Assignee

• SYNERGY PHARMACEUTICALS, INC. · US

Inventors

• Kunwar Shailubhai · Audubon, US
• Stephen Comiskey · Doylestown, US
• Rong Feng · Langhorne, US
• Juncai Bai · North Augusta, US
• Ruoping Zhang · Penn Hills, US
• Jun Jia · Beijing, CN
• Junfeng Zhou · Redmond, US
• Qiao Zhao · Shanghai, CN
• Guoqing Zhang · Beijing, CN

Key dates

• Filing date: Jun 5, 2014
• Grant date: Jul 3, 2018
• Expiry date: Jun 5, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y406/01002
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.