Constructs targeting AFP peptide/MHC complexes and uses thereof

US10011658B2 · kind B2 · utility

Assignee

• Eureka Therapeutics, Inc. · US

Inventors

• Cheng Liu · Richmond, US
• Hong Liu · Seattle, US
• Yiyang Xu · Pleasanton, US
• Jingyi Xiang · Walnut Creek, US
• Li Long · Hercules, US

Key dates

• Filing date: Dec 1, 2017
• Grant date: Jul 3, 2018
• Expiry date: Dec 1, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I protein. Also provided are methods of making and using these constructs.