Targeted sequencing technique for whole genome DNA methylation
US10011867B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 13, 2014 |
| Grant date | Jul 3, 2018 |
| Priority date | — |
| Expiry date | Oct 18, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6869
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention is directed to a guide positioning sequencing technology of whole-genome DNA methylation. The invention provides a new detection method of nucleic acid methylation. In particular, a concept of “positioning” in the detection of nucleic acid methylation is provided. Specifically, a portion of a sequence is used for genome wide positioning and the other portion of the sequence is used for methylation detection in sequencing, thereby solving/defeating previously existing challenges in methylation detection and bioinformatics analysis of a genome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.