Non-human animals having a humanized cluster of differentiation 47 gene
US10015953B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jan 19, 2016 |
| Grant date | Jul 10, 2018 |
| Priority date | — |
| Expiry date | Jan 19, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70596
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (CD) gene, in particular a humanization of a CD47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD47 gene so that said non-human animals express a CD47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.