Methods for treatment of melanoma
US10016402B2 · kind B2 · utility
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3References
12Claims
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Key dates
| Filing date | Jun 8, 2015 |
| Grant date | Jul 10, 2018 |
| Priority date | — |
| Expiry date | Jun 8, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the present invention are directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods comprise screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.