Compositions and methods of enhancing immune responses to Eimeria

US10016493B2 · kind B2 · utility

Assignees

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Walter Bottje · Fayetteville, US
• Billy Hargis · Fayetteville, US
• Luc Berghman · College Station, US
• Young Min Kwon · West Fork, US
• Kimberly Cole · Raymond, US
• Mandy Cox · Fayetteville, US
• Sherryll Layton · Fayetteville, US
• Saeed El-Ashram
• John R. Barta · Guelph, CA
• Guillermo Tellez · Fayetteville, US

Key dates

• Filing date: Feb 16, 2015
• Grant date: Jul 10, 2018
• Expiry date: Feb 16, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.