Benzoxazinone amides as mineralocorticoid receptor modulators

US10017502B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Gavin O'Mahony · Timrå, SE
• Michael Kossenjans · Mölndal, SE
• Karl Edman · Timrå, SE
• Johan Kajanus · Timrå, SE
• Carl Anders Hogner · Mölndal, SE
• Philip Cornwall · Grafton, GB
• Andrew Turner · Macclesfield, GB

Key dates

• Filing date: Jun 26, 2015
• Grant date: Jul 10, 2018
• Expiry date: Jun 26, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.