Thiol-X click foldamers for polymer affinity and catalysis libraries

US10017510B2 · kind B2 · utility

Assignee

• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Christopher N. Bowman · Boulder, US
• Christopher J. Kloxin · Eckernförde, DE
• Weixian Xi · Pasadena, US
• Tao Gong · Beijing, CN
• Sankha Pattanayak · Mountain View, US

Key dates

• Filing date: Feb 6, 2015
• Grant date: Jul 10, 2018
• Expiry date: Feb 6, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6876
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.