Block copolymer and micelle compositions and methods of use thereof

US10017598B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jinming Gao · Dallas, US
• David Boothman · Dallas, US
• Kejin ZHOU · Dallas, US
• Xiaonan Huang · Beijing, CN
• Yiguang Wang · Dallas, US

Key dates

• Filing date: Jul 27, 2017
• Grant date: Jul 10, 2018
• Expiry date: Jul 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F2438/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.