Gene transfer into airway epithelial stem cell by using lentiviral vector pseudotyped with RNA virus or DNA virus spike protein
US10017784B2 · kind B2 · utility
0Cited by
17References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 17, 2014 |
| Grant date | Jul 10, 2018 |
| Priority date | — |
| Expiry date | Nov 17, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/609
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.