Three-dimensional electronic scaffold for cardiac applications

US10018615B2 · kind B2 · utility

Assignee

• Lawrence Livermore National Security, LLC · US

Inventors

• Fang Qian · Santa Cruz, US
• Mihail Bora · Livermore, US
• Eric B. Duoss · Danville, US
• Christopher M. Spadaccini · Oakland, US
• Cheng Zhu · Livermore, US

Key dates

• Filing date: Mar 8, 2016
• Grant date: Jul 10, 2018
• Expiry date: Jul 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed here is a three-dimensional electronic scaffold, comprising a porous scaffold and a plurality of micro-strain gauges distributed spatially inside the porous scaffold, wherein the micro-strain gauges are adapted to detect contraction force. Also disclosed is a method comprising detecting and mapping intra-tissue cardiac contraction force of one or more cardiac cells or tissues disposed in a three-dimensional electronic scaffold, wherein the three-dimensional electronic scaffold comprises a porous scaffold and a plurality of micro-strain gauges distributed spatially inside the porous scaffold and in contact with the cardiac cells or tissues, and wherein the micro-strain gauges are adapted to detect contraction force of the cardiac cells or tissues.