Patent · US Active

Cationic materials and formulations for drug delivery

US10022334B2 · kind B2 · utility

7Cited by

4References

25Claims

0Family size

Assignee

The Brigham and Women's Hostpital, Inc. · US

Inventors

Omid C. Farokhzad · Sharon, US
Jun Wu · Houston, US
Lili Zhao · Boston, US

Key dates

Filing date	Dec 5, 2014
Grant date	Jul 17, 2018
Priority date	—
Expiry date	Dec 5, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08G81/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (a-amino acid)-α, ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.