Pyrazolopyridines and pyrazolopyrimidines

US10022376B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Jotham Wadsworth Coe · Niantic, US
• Christoph Martin Dehnhardt · New York, US
• Peter Jones · Sharon, US
• Yogesh Anil Sabnis · Sandwich, GB
• Joseph Walter Strohbach · Mendon, US
• Florian Wakenhut · Sandwich, GB
• Gavin Alistair Whitlock · Sandwich, GB

Key dates

• Filing date: Nov 3, 2016
• Grant date: Jul 17, 2018
• Expiry date: Nov 3, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound having the structure: or a pharmaceutically acceptable salt or solvate thereof, wherein A and A′ are C or N, where C may be substituted by halo or C1-C6 alkyl; R and R0 are selected from the group consisting of H, C1-C6 alkyl, —(CH2)n—W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR″SO2—R′, etc., where R′ and R″ are C1-C6 alkyl, etc.; wherein each alkyl, etc., may be substituted; or, R and Ro and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.; R1 is H, halo or cyano; R2 and R2′ are H, C1-C6 alkyl, etc.; X is a bond, etc.; R3 is H, C1-C4 alkyl, etc.; Y is a bond, —(CH2)m—, etc. The invention also relates to compositions and uses in the treatment of various diseases.