Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP)

US10022453B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Hans-Georg Lerchen · Leverkusen, DE
• Sven Wittrock · Berlin, DE
• Nils Griebenow · Milford, US
• Beatrix Stelte-Ludwig · Wülfrath, DE
• Anette SOMMER · Berlin, DE
• Sandra BERNDT · Hohen Neuendorf, DE
• Christoph MAHLERT · Wuppertal, DE
• Mario Lobell · Wuppertal, DE
• Carsten TERJUNG · Bochum, DE
• Simone Greven · Dormagen, DE
• Yolanda Cancho Grande · Leverkusen, DE

Key dates

• Filing date: Dec 10, 2014
• Grant date: Jul 17, 2018
• Expiry date: Dec 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel antibody drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.