Device for processing a liquid medium comprising cells

US10022732B2 · kind B2 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventors

• Artur Meisberger · Sankt Wendel, DE
• Melanie Fahrendorff · Troisdorf, DE
• Michael Brinkmann · Florstadt, DE
• Martin Biehl · Wittenberg, DE

Key dates

• Filing date: Dec 17, 2014
• Grant date: Jul 17, 2018
• Expiry date: Dec 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.