Process and intermediates for preparing poly(anhydride-esters)

US10023521B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Kathryn E. Uhrich · New Brunswick, US
• Jonathan James Faig · Sayreville, US
• Kervin Smith · New Brunswick, US

Key dates

• Filing date: Jun 10, 2015
• Grant date: Jul 17, 2018
• Expiry date: Jun 10, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/59
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.