Glutathione-cleavable prodrug and methods of use thereof
US10023551B2 · kind B2 · utility
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Key dates
| Filing date | May 12, 2016 |
| Grant date | Jul 17, 2018 |
| Priority date | — |
| Expiry date | May 12, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/64
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.