G protein-coupled receptor kinase 2 inhibitors and methods for use of the same

US10023564B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Scott D. Larsen · Kalamazoo, US
• Kristoff Homan · Newton, US
• Helen Waldschmidt · Ann Arbor, US
• John J. Tesmer · Ann Arbor, US

Key dates

• Filing date: Aug 10, 2015
• Grant date: Jul 17, 2018
• Expiry date: Aug 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.