Patent · US Active

6-aryl amino pyridone formamide compound crystal and preparation method therefor

US10023582B2 · kind B2 · utility

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17Claims

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Inventors

Lulu Wang · Shanghai, CN
Xiquan Zhang · 安丰镇, CN
Fei Liu · Nanjing, CN
Yizhong Zhu · Lianyungang, CN
Chao Gao · Guilin, CN
Song Tang · Lianyungang, CN
Bo Zhu · Shenyang, CN
Jianqiu Tang · Lianyungang, CN

Key dates

Filing date	Aug 5, 2015
Grant date	Jul 17, 2018
Priority date	—
Expiry date	Aug 5, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxylethyoxyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-carboxamide in an aprotic polar solvent and adding a second solvent thereto. The crystallization method has the advantage of simple and convenient operations, and is beneficial to an industrial production. The resulting crystal has the advantage a high purity and good stability, and is benefit to the manufacture and storage of a medicament containing the same.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.