Endothelial and endothelial like cells produced from fibroblasts and uses related thereto
US10023842B2 · kind B2 · utility
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Key dates
| Filing date | Apr 29, 2015 |
| Grant date | Jul 17, 2018 |
| Priority date | — |
| Expiry date | Apr 29, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1307
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of producing endothelial or endothelial like cells comprising exposing fibroblasts with ETV2 under conditions such that the fibroblasts are modified to form a pool of cells expressing increased levels of endothelium surface markers compared to the fibroblasts. In certain embodiments, the disclosure relates to using endothelial like cells reported herein for the treatment of vascular, cardiac, and wound healing indications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.