Therapeutics with conformationally restricted monomers
US10023863B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Feb 17, 2015 |
| Grant date | Jul 17, 2018 |
| Priority date | — |
| Expiry date | Feb 17, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention provides single-stranded and multi-stranded compounds that are useful in various therapeutic modalities to regulate the expression of nucleic acid molecules in a cell. A range of compounds is provided, each containing one or more conformationally restricted nucleomonomers (CRN). In addition, compounds can contain one or more conformationally restricted nucleomonomers and one or more hydroxymethyl substituted nucleomonomers (unlocked nucleomonomers, UNA).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.