Analysis of dried blood spot samples in a microfluidic system with dilution of extracted samples
US10024826B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 22, 2012 |
| Grant date | Jul 17, 2018 |
| Priority date | — |
| Expiry date | Dec 5, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/062
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.