Immunostimulatory compositions and methods of use thereof

US10029016B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Darrell J. Irvine · Arlington, US
• Haipeng Liu · Beijing, CN

Key dates

• Filing date: Jul 2, 2015
• Grant date: Jul 24, 2018
• Expiry date: Jul 2, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.