Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof
US10029996B2 · kind B2 · utility
0Cited by
0References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 15, 2014 |
| Grant date | Jul 24, 2018 |
| Priority date | — |
| Expiry date | Nov 12, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.