Patent · US Active

Method for the synthesis of clofarabine

US10030043B2 · kind B2 · utility

1Cited by

0References

8Claims

0Family size

Assignee

SYNBIAS PHARMA AG · CH

Inventors

Alexander Zabudkin · Donetsk, UA
Victor Matvienko · Donetsk, UA
Iaroslav Matviienko · Mannheim, DE
Volodymyr Sypchenko · Mannheim, DE

Key dates

Filing date	Apr 22, 2015
Grant date	Jul 24, 2018
Priority date	—
Expiry date	May 5, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a method for the high yield production of the anticancer nucleoside clofarabine, the method comprising the preparation of 2-chloroadenosine by enzymatic transglycosylation between 2-chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.