Nucleotides for the treatment of liver cancer
US10030044B2 · kind B2 · utility
4Cited by
0References
46Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 25, 2014 |
| Grant date | Jul 24, 2018 |
| Priority date | — |
| Expiry date | Nov 25, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/708
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z1, Z2, Z3, Z4, V, W, X, Ar, R1 and R2 are as described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.