Patent · US Active

Modified gram positive bacteria and uses thereof

US10030234B2 · kind B2 · utility

2Cited by

2References

18Claims

0Family size

Assignee

INTREXON ACTOBIOTICS N.V. · BE

Inventors

Lothar Steidler · Lokeren, BE
Karolien Van Huynegem · Asper, BE
Klaas Vandenbroucke · Zevergem, BE

Key dates

Filing date	Sep 7, 2016
Grant date	Jul 24, 2018
Priority date	—
Expiry date	Sep 7, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/86
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.